Experiment 7480
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Camptotheca acuminata (NYSSACEAE) |
| Citation | GOTTLIEB,JA: LUCE,JK:. (1972). TREATMENT OF MALIGNANT MELANOMA WITH CAMPTOTHECIN (NSC-100880).. 56() |
| Amount utilized | |
| Compound isolated | |
| Disease | CLINICAL STUDY INVOLVING 15 PATIENTS WITH ADVANCED MALIGNANT MELANOMA.AGE OF SUBJECTS WAS 28-72 YEARS:9 MEN + 6 WOMEN:10 WERE REFRACTORY TO PREVIOUS CHEMOTHERAPY.12/15 PATIENTS RECEIVED NONE OF PATIENTS DEMONSTRATED A GREATER THAN 50% DECREASE IN TUMOR DIAMETER MEDIAN SURVIVAL TIME FOR ALL 15 PATIENTS WAS 5+ MONTHS TOXIC SYMPTOMS INCLUDED MYELOSUPPRESSION(11 PATIENTS), NAUSEA + VOMITING(9 PATIENTS), ALOPECIA(8 PATIENTS), DIARRHEA(3 PATIENTS), HEMORRHAGIC CYSTITIS(1 PATIENT) |
| Dose amount | 120.0 MG |
| Number | 1 |
| Qualitative result | INACTIVE |
| Animal | HUMAN ADULT |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |