Experiment 75292

Worktypes

PHARMACOLOGY OF COMPOUND - IN VIVOEFFECTS DUE TO A COMBINATION OF DRUGSANTICANCER AND/OR CYTOTOXICITY MARKER CODE

Compounds isolated

PEPLOMYCIN

Alerts

A MIXTURE OF PURE COMPOUNDS WAS USED TO OBTAIN THE REPORTED EFFECT.DATA INCOMPLETE - DERIVED FROM AN ABSTRACT.

Details

PropertyValue
Pharmacology
ANTITUMOR ACTIVITY
Administration routeROUTE NOT GIVEN
OrganismEmpty organism
CitationISHII,Y: EKIMOTO,H: NISHIKAWA,K: TAKAHASHI,K: MATSUDA,A:. (1984). EXPERIMENTAL STUDIES ON PEPLOMYCIN, A NEW DERIVATIVE OF BIEOMYCIN.. 10(10)
Amount utilized
Compound isolated
DiseaseHAD A SYNERGISTIC EFFECT WHEN GIVEN WITH THE DNA TARGETING ANTITUMOR AGENTS CYCLOPHOSPHAMIDE, NIMUSTINE,CISPLATIN,MITOMYCIN C AND DOXORUBICIN. IT HAD AN ADDITIVE EFFECT WITH 5-FU,ARA-C,METHOTREXATE. IT HAD A VARIABLE RESPONSE WHEN MIXED WITH VINBLASTINE,ZYMOSAN OR ETOPOSIDE.
Number8
Qualitative resultACTIVE
AnimalMOUSE
Dose expressionDOSE