Experiment 759113
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Organism | Agave attenuata (AGAVACEAE) |
| Citation | BRACKENBURY,TD:. (1999). GROSS HISTOPATHOLOGICAL EFFECTS OF AN EXTRACT OF AGAVE ATTENUATA ON THE EPITHELIUM OF THE DIGESTIVE TRACT OF BULINUS AFRICANUS.. 93(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | A LETHAL CONCENTRATION OF A CRUDE, AQUEOUS EXTRACT OF AGAVE ATTENUATA WAS APPLIED AS A CONTACT POISON TO BULINUS AFRICANUS, THE INTERMEDIATE HOST OF SCHISTOSOMA HAEMATOBIUM, FOR A 24-H PERIOD. THE GORSS HISPTOPAHTOLOGICAL EFFECTS OF THE EXTRACT ON THE EPITHELIUM OF THE DIGESTIVE TRACT WERE THEN STUDIED. A GRADED SERIES OF CELLULAR INJURIES TO THE EPITHELIAL LAYER WAS OBSERVED ALONG THE LENGTH OF THE TRACT. THESE INCLUDED THE LOSS OF CILIA AND BRUCH BORDER, DISCRUPTION OF THE EPITHELIAL LAYER, CELLULAR VACUOLATION, SWELLING AND RUPTURE, AND THE DISCHARGE OF SECRETORY PRODUCTS FORM MUCOSUS GLAND CELLS. THE RESULTS OF THE MICROSCOPY SHOW THE EPITHELIAL TISSUE IS PROBARLY A PRIMARY TARGET OF THE MOLLUSCICIDE. THE CYTOLOGICAL INJURIES INDUCED BY EXTRACTS OF A. ATTENUATA INDICATES THE THE MOLLUSCICIDE ACTS BY DISRUPTING THE OSMOREGULATORY MECHANISM OF THE EPITHELIAL CELLS. |
| Dose amount | 65.0 PPM |
| Number | 1 |
| Qualitative result | ACTIVE |
| Dose expression | DOSE |
| Extract | H2O EXT |