Experiment 75981
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Empty organism |
| Citation | DODION,P: EGORIN,MJ: ENGISCH,KL: BACHUR,NR:. (1985). METABOLISM AND DISPOSITION OF MENOGARIL (NSC 269 148) IN THE RABBIT.. 45(11) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE PEAK PLASMA CONCENTRATION WAS 1.2 UM. PLASMA ELIMINATION WAS BIEXPONENTIAL WITH A TERMINAL HALF LIFE OF 2.66 HRS. THE APPARENT VOLUME OF THE CENTRAL COMPARTMENT WAS 2.22 LITER/KG. THE AREA UNDER THE PLASMA CONCENTRATION VERSUS TIME CURVE WAS 1.34 UM X H. TOTAL BODY CLEARANCE WAS 57.6 ML/MIN/KG. THE RATE OF EXCRETION WAS APPROXIMATELY 10 MCG/H. CUMULATIVE BILIARY EXCRETION AFTER 8 H WAS 3.4% OF TOTAL DOSE. ORGAN CONCENTRATIONS FROM THE HIGHEST TO THE LOWEST WERE: LUNGS, HEART, PANCREAS, SKELETAL MUSCLE, SPLEEN, DUODEMUM, LIVER, SMALL INSTESTINE, KIDNEY AND BRAIN. |
| Dose amount | 2.5 MG |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | RABBIT |
| Per unit | KG |
| Dose expression | DOSE |