Experiment 75990
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Empty organism |
| Citation | UZUKA,Y: SAITO,Y:. (1985). TREATMENT OF CHRONIC MYELOGENOUS LEUKEMIA IN BLASTIC CRISIS WITH CHEMOTHERAPY INCORPORATING VINDESINE-PREDNISOLONE.. 69(11) |
| Amount utilized | |
| Compound isolated | |
| Disease | IN THIS STUDY,23 PATIENTS IN THE TERMINAL PHASE OF CHRONIC MYELOGENOUS LEUKEMIA WERE TREATED WITH COMBINATION CHEMOTHERAPY OF VINDESINE,PREDNISOLONE,CYTARABINE AND 6-MERCAPTOPURINE. OF THE 21 PATIENTS WITH BLASTIC CRISIS,15 (71.4%) ACHIEVED COMPLETE REMISSION. THESE REMISSIONS CAN BE DIVIDED UP BY DISEASE CONDITION AS FOLLOWS: 5/5 WITH LYMPHOID MORPHOLOGY,10/12 WITH MYELOID MORPHOLOGY,AND 0/4 WITH MONOCYTOID MORPHOLOGY. THE MEDIAN TIME FROM INITIATION OF THERAPY TO COMPLETE REMISSION WAS 29 DAYS,AND THE MEDIAN DURATION WAS FROM 5 TO 107 WEEKS. MYELOSUPPRESSION WAS SEEN IN ALL RESPONDERS. NO NEUROTOXICITY WAS OBSERVED. |
| Dose amount | 1.3 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |