Experiment 75991

Details

PropertyValue
Pharmacology
Administration routeORAL
OrganismEmpty organism
CitationUZUKA,Y: SAITO,Y:. (1985). TREATMENT OF CHRONIC MYELOGENOUS LEUKEMIA IN BLASTIC CRISIS WITH CHEMOTHERAPY INCORPORATING VINDESINE-PREDNISOLONE.. 69(11)
Amount utilized
Compound isolated
DiseaseIN THIS STUDY,23 PATIENTS IN THE TERMINAL PHASE OF CHRONIC MYELOGENOUS LEUKEMIA WERE TREATED WITH COMBINATION CHEMOTHERAPY OF VINDESINE,PREDNISOLONE,CYTARABINS AND 6-MERCAPTOPURINE. OF THE 21 PATIENTS WITH BLASTIC CRISIS,15 (71.4%) ACHIEVED COMPLETE REMISSION. THESE REMISSIONS CAN BE DIVIDED UP BY DISEASE CONDITION AS 10/12 WITH MYELOID MORPHOLOGY,AND 0/4 WITH MONOCYTOID MORPHOLOGY. THE MEDIAN TIME FROM INITIATION OF THERAPY TO COMPLETE REMISSION WAS 29 DAYS,AND THE MEDIAN DURATION WAS FROM 5 TO 107 WEEKS. MYELOSUPPRESSION WAS SEEN IN ALL RESPONDERS. NO NEUROTOXICITY WAS OBSERVED.
Dose amount20.30 MG
Number1
Qualitative resultACTIVE
AnimalHUMAN ADULT
Per unitSQ M BODY SURFACE
Dose expressionDOSE