Experiment 764213
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INTRAGASTRIC |
| Organism | Tripterygium wilfordii (CELASTRACEAE) |
| Citation | ZHENG,JR: FANG,JL: XU,LF:. (1985). EFFECTS OF TOTAL GLYCOSIDES OF TRIPTERYGIUM WILFORDII ON THE REPRODUCTIVE ORGANS OF EXPERIMENTAL ANIMAL. II EXPERIMENTS IN FEMALE RATS.. 7(4) |
| Amount utilized | |
| Compound isolated | |
| Disease | FOLLOWING ORAL ADMINISTRATION TO THE TOTAL GLYCOSIDES OF T. WILFORDII (30 MG/KG, DAILY FOR 35-80 DAYS) TO FEMALE RATS, THE ESTRUAL CYCLE BECAME IRREGULAR IN 80-90% OF THE ANIMALS (OVARIAN FUNCTION WAS NORMAL), WT. OF THE UTERUS WAS 27.8-43.2% LESS THAN THAT OF THE CONTROL, SMOOTH MUSCLE FIBERS OF THE MYOMETRIUM BECAME THINNER, CELL ORGANELLES OF GLAND CELLS IN THE ENDOMETRIUM DECREASED, AND LYSOSOMES OF THE SMOOTH MUSCLE CELLS INCREASED; PLASMA ESTRADIOL [50-28-2] AND PROGESTERONE [57-83-0] LEVELS WERE NORMAL. COMPARED TO THE TOXIC EFFECTS OF THE GLYCOSIDES ON MALE ORGANS (EARLIER REPORTS), FEMALE REPRODUCTIVE ORGANS ARE LESS AFFECTED BY THESE DRUGS. |
| Dose amount | 30.0 MG |
| Number | 1 |
| Qualitative result | INACTIVE |
| Animal | RAT |
| Per unit | KG |
| Dose expression | DOSE |
| Extract | CHROMATOGRAPHIC FRACTION |
| Gender | FEMALE |