Experiment 764283

Compounds isolated

Details

PropertyValue
Pharmacology
OrganismEmpty organism
CitationUHING,MR: GOLDMAN,AS: GOTO,MP:. (1993). CYCLOSPORIN A-INDUCED EMBRYOPATHY IN EMBRYO CULTURE IS MEDIATED THROUGH INHIBITION OF THE ARACHIDONIC ACID PATHWAY.. 202(3)
Amount utilized
Compound isolated
DiseaseEMBRYOS SHOWED A 78.6% INCREASE IN THE INCIDENCE OF MALFORMATIONS AS COMPARED TO 6.8% IN CONTROL EMBRYOS. MALFORMATION INCLUDED DEFECTS OF THE NEURAL TUBES HEAD FOLDS AND FACIAL ARCHES. TREATMENT OF CULTURE WITH ARACHIDONIC ACID OR PROSTAGLANOIN E-2 REDUCED MALFORMATIONS TO 50% AND 70% RESPECTIVELY.
Dose amount10.0 MCG
Number1
Qualitative resultACTIVE
AnimalMOUSE
Per unitML
Dose expressionCONC USED
GenderFEMALE