Experiment 764289
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Empty organism |
| Citation | XUE,M: CUI,Y: WANG,HQ: LUO,YJ: ZHANG,B: ZHOU,ZT:. (1999). PHARMACOKINETICS OF CRYPTOTANSHINONE AND ITS METABOLITE IN PIGS.. 34(2) |
| Amount utilized | |
| Compound isolated | |
| Disease | TO STUDY THE PHARMACOKINETICS AND EXCRETION OF THE ANTIBACTERIAL CONSTITUENT CRYPTOTANSHINONE (CT) ISOLATED FROM THE ROOTS OF SALVIA PRZEWALSKII MAXIM. (LABIATAE) AND ITS METABOLITE TANSHINONE IIA(TS) IN PIGS, NORMAL PIGS WERE GIVEN CT IV 10 MG/KG. THE CONCENTRATIONS OF CT AND TS IN PORCINE PLASMA, URINE AND BILE WERE DETERMINED BY AN HPLC METHOD. PLASMA DRUG CONCENTRATION-TIME COURSE OF CT AFTER IV ADMINSTRATION OF CT WAS FOUND TO BE FITTED TO A TWO COMPARTMENT OPEN MODEL AND ITS PHARMACOKINETIC PARAMETERS WERE AS FOLLOWS: TS WAS DETECTED SIMULTANEOUSLY. PEAK PLASMA CONCENTRATION OF TS WAS REACHED AT ABOUT 4.6 MINUTES AFTER DOSING. THE EXCRETION OF CT AND TS IN URINE AND BILE IN 24-28 HOURS WAS VERY LITTLE AFTER IV AND PO ADMINISTRATION OF CT. |
| Dose amount | 10.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | PIG(CASTRATE) |
| Per unit | KG |
| Dose expression | DOSE |
| Gender | MALE |