Experiment 77694
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Organism | Sophora flavescens (FABACEAE) |
| Citation | YAMAZAKI,M: ARAI,A:. (1985). ON THE CONTRACTILE RESPONSE OF FUNDUS STRIP FROM RATS TO MATRINE, AN ALKALOIDAL COMPONENT OF SOPHORA FLAVESCENS.. 8(7) |
| Amount utilized | |
| Compound isolated | |
| Disease | TETRODOTOXIN (10-6 G/ML) AND PHENTOLAMINE (10-5 G/ML) POTENTIATED THE MAXIMUM CONTRACTION. ATRODINE (10-4 G/ML) WAS UNAFFECTIVE, AS WAS METHYSERGIDE (10-6 G/ML). THERE WAS A LOSS OF CONTRACTION IN THE PRESENCE OF H1-RECEPTOR ANTAGONISTS. THESE INCLUDE DIPHENHYDRAMINE (10-5 G/ML) AND CHLORPHENIRAMINE (10-5 G/ML). PYRILAMINE ANTAGONIZED THE CONTRACTILE RESPONSE TO MATRINE AND THE RESPONSE WAS REDUCED BY ANTIHISTAMINES. PROCAINE REDUCED, BUT DID NOT INHIBIT CONTRACTION. |
| Dose amount | 20.0 MG |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | ML |
| Dose expression | CONC USED |