Experiment 781533
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INTRAGASTRIC |
| Organism | Eleutherococcus senticosus (ARALIACEAE) |
| Citation | FUJIKAWA,T: SOYA,H: HIBASAMI,H: KAWASHIMA,H: TAKEDA,H: NISHIBE,S: NAKASHIMA,K:. (2002). EFFECT OF ACANTHOPANAX SENTICOSUS HARMS ON BIOGENIC MONOAMINE LEVELS IN THE RAT BRAIN.. 16(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | SHOWED A MARKED INCREASE IN THE DA LEVEL ONLY IN THE STRIATUM. HOWEVER, NA LEVELS WERE INCREASED BY A SINGLE DOSE OF ASH IN A WIDE RANGE OF BRAIN REGIONS SUCH AS THE CORTEX, HYPOTHALAMUS, STRIATUM, HIPPOCAMPUS, SUBSTANTIA NIGRA AND PONS. WHEN ADMINISTERED FOR 2 WEEKS NO INCREASE IN NA LEVELS WAS SEEN IN THESE BRAIN REGIONS, EXCEPT FOR AN INCREASE IN THE FRONTAL CORTEX AN DANTERIOR HYPOTHALAMUS. THE PRESENT RESULTS SUGGEST THAT ASH MAY ACT BY REGULATING NA AND DA LEVELS IN SPECIFIC BRAIN REGIONS RELATED TO STRESS RESPONSE AND PARKINSON'S DISEASE. |
| Dose amount | 500.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | KG |
| Dose expression | DOSE |
| Extract | ETOH(100%)EXT |
| Gender | MALE |