| Disease | FOUR GROUPS OF TO STRAIN: CONTROL, CONTROL-GARLIC TREATED, DEHYDRATED, AND DEHYDRATED-GARLIC TREATED MALE MICE, 10/GROUP, WERE USED. DEHYDRATION WAS INDUCED BY WATER DEPRIVATION FOR 24 HR. GARLIC SOLUTION WAS I.P. INJECTED AT 01. ML/10 G BODY
WEIGHT. IN URETHANE-ANESTHETIZED (2 MG/G, I.P.) MICE, TOPICAL AND TRANSVESSEL BIMODAL FIXATION OF PIAL MICROVESSELS WAS DONE WITH A PHOSPHATE BUFFERED MIXTURE OF GLUTARALDEHYDE AND PARAFORMALDEHYDE, FOLLOWED BY A CONVENTIONAL ELECTRON
MICROSCOPY PROCEDURE. GARLIC TREATMENTS DID NOT CAUSE ANY ULTRASTRUCTURE ABNORMALITIES IN CONTROL MICE. COMPARED WITH CONTROL, DEHYDRATION CAUSED THE APPEARANCE OF THROMBI THAT CONSISTED OF PLATELET AGGREGATES. DISCOID PLATELETS CONTAINING
GRANULES, SPHEROID DEGRANULATED PLATELETS, AND THOSE WITH LARGE PESUDOPODIA WERE PRESENT IN 80% OF DEHYDRATED MICE. THE VENULAR ENDOTHELIAL SURFACE OF DEHYDRATED MICE REVEALED DILATED PROFILES OF ENDOPLASMIC RETICULUM AND VARIOUSLY SHAPED
VAUCOLES. SWELLING OF NUCLEAR ENVELOPES AND MITOCHONDIRAL DISTENSION WERE ALSO PRESENT IN DEHYRATED MICE. CONCOMITANT GARLIC TREATMENT PREVENTED MOST OF THESE ULTRASTRUCTURAL CHANGES. THESE FINDINGS DEMOSTRATED THE EXTENT OF DAMAGE TO THE PIAL
MICROVESSELS IN RESPONSE TO WATER DEPRIVATION AND DEMOSTRATED THE BENEFICIAL EFFECT OF GARLIC AS A POSSIBLE MEAN OF PROTECTION AGAINST ONCOMING VASCULAR PAHTOLOGY. |