Experiment 784216
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Cimicifuga racemosa (RANUNCULACEAE) |
| Citation | KNUVENER,E: KORTE,B: WINTERHOFF,H:. (2000). CIMICIFUGA AND PHYSIOLOGICAL ESTROGENS.. 7() |
| Amount utilized | |
| Compound isolated | |
| Disease | TREATMENT WITH THE PLANT EXTRACT IN DAILY DOSES FROM 50 TO 600 MG CAUSED NO ESTROGENIC EFFECTS IN VAGINAL SMEARS. TO SEARCH FOR ANTIESTROGENIC ACTIVITY ANIMALS WERE TREATED WITH 75 UG/KG BW/D MESTRANOL AND CONCOMITANTLY WITH THE PLANT EXTRACT IN DAILY DOSAGES FROM 50 TO 250 MG/KG BW. IN MICE TREATED WITH THE COMBINATION THE PERIOD OF POSITIVE VAGINAL SMEARS WAS SIGNIFICANTLY INCREASED AS COMPARED TO THE HORMONE REFERENCE GROUP. COMPARABLE RESULTS WERE OBTAINED AFTER COMBINED TREATMENT WITH 17-BETA ESTRADIOL AND THE PLANT EXTRACT. |
| Dose amount | 600.0 MG |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | MOUSE |
| Dose expression | DOSE |
| Extract | ETOH(35%)EXT |
| Gender | FEMALE |