Experiment 784623
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INTRAGASTRIC |
| Organism | Empty organism |
| Citation | BUTTERWECK,V: BOCKERS,T: KORTE,B: WITTKOWSKI,W: WINTERHOFF,H:. (2002). LONG-TERM EFFECTS OF ST. JOHN'S WORT AND HYPERICIN ON MONOAMINE LEVELS IN RAT HYPOTHALAMUS AND HIPPOCAMPUS.. 930(1/2) |
| Amount utilized | |
| Compound isolated | |
| Disease | SIGNIFICANTLY INCREASED 5-HT LEVELS IN THE HYPOTHALAMUS (P<0.05). THE 5-HT TURNOVER WAS SIGNIFICANTLY LOWERED IN BOTH BRAIN REGIONS AFTER 8 WEEKS OF DAILY TREATMENT WITH THE HYPERICUM EXTRACT (BOTH P<0.05). CONSISTENT CHANGES IN CATECHOLAMINE LEVELS WERE ONLY DETECTED IN HYPOTHALAMINE TISSUES AFTER LONG-TERM TREATMENT. COMPARABLE TO IMIPRAMINE, HYPERICUM EXTRACT AS WELL AS HYPERICIN SIGNIFICANTLY DECREASED 3,4-DIHYDROXYPHENYLACETIC ACID AND HOMOVANILLIC ACID LEVELS IN THE HYPOTHALAMUS (P<0.01). |
| Dose amount | 0.2 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | KG |
| Dose expression | DOSE |
| Gender | MALE |