Experiment 789814
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Ginkgo biloba (GINKGOACEAE) |
| Citation | KRESSMANN,S: BIBER,A: WONNEMANN,M: SCHUG,B: BLUME,HH: MULLER,WE:. (2002). INFLUENCE OF PHARMACEUTICAL QUALTIY OF THE BIOAVAILABILITY OF ACTIVE COMPONENTS FROM GINKGO BILOBA PREPARATIONS.. 54(11) |
| Amount utilized | |
| Compound isolated | |
| Disease | GINKGO BILOBA CAPSULES (REFERENCE PRODUCT: GINKGOLD) WERE ANALYSED FOR DISSOLUTION RATES AND BIOAVAILABILITY OF THE MOST RELEVANT ACTIVE INGREDIENTS. DISSOLUTION RATES OF PH 1 AND 4.5 WERE DETERMINED ACCORDING TO THE USP 23. THE RELATIVE BIOAVAILABILITY OF GINKGOLIDE A, GINKGOLIDE B AND BILOBALIDE WAS INVESTIGATED AFTER SINGLE ORAL ADMINISTRATION OF 120 MG GINKGO BILOBA EXTRACT AS TABLETS OR CAPSULES. BIOAVAILABILITY DATA (AREA UNDER THE CURVE AND PEAK CONCENTRATION IN PLASMA) WERE CLEARLY DIFFERENT AND DID NOT SHOW BIOEQUIVALENCE OF TEST AND REFERENCE PRODUCTS. THE SLOW IN-VITRO DISSOLUTION OF THE TEST PRODUCT RESULTED IN A LARGE DECREASE IN BIOAVAILABILITY. THESE RESULTS INDICATE FOR THE FIRST TIME THAT THE PHARMACEUTICAL PROPERTIES OF A HERBAL MEDICINAL PRODUCT HAVE A SIGNIFICANT IMPACT ON THE RATE AND EXTENT OF DRUG ABSORPTION, AND VERY LIKELY ON EFFICACY IN HUMANS. |
| Dose amount | 120.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | ACETONE EXT |
| Gender | GIVEN TO BOTH SEXES |