| Disease | THE PLASMA LEVELS DISPLAYED CURVES CHARACTERIZED BY MAXIMUM PEAKS AT 8.3(DL)-5.2MIN, 8.3(DL)-5.2MIN AND 20.0(D.)-21.9MIN FOLLWING DOSAGES OF 125, 250 AND 500MG/KG WITH MEAN CONCENTRATIONS OF 1302(DL)-926.4, 2973.6(DL)-684.3 AND 3118.8(DL)-
1701.2NG/ML, RESPECTIVELY, FOLLOWED BY A SUBSEQUENT DECLINE. AREA UNDER THE CONCENTRATION-TIME CURVE (AUC)(0-48H) AT DOSES OF 125,250 AND 500MG/KG WERE (DL)-321.5,2443.3(DL)-554.4 AND 4443.2(DL)-2641.3NG.H/ML, RESPECTIVELY. IN FEMALE RATS,
RHEIN PLASMA LEVELS SHOWED CURVES WHICH HAD A MAXIMUM PEAK AT 45.0(DL)-16.4MIN AFTER A DOSAGE OF 250MG/KG WITH MEAN CONCENTRATION OF 3058.0(DL)-1533.7NG/ML, FOLLWED BY A SUBSEQUENT DECLINE. AUC(0-48H) WAS 5537.7(DL)-1876.0NG.H/ML. THE CUMULATIVE
URINARY EXCRETION OF RHEIN AND OF CONJUGATED RHEIN WAS 3.14(DL)-1.56% AND 38.21(DL)-18.87% OF DOSE, RESPECTIVELY, 48H AFTER DOSING AT 500MG/KG OF ONPI-TO IN MALE RATS. THE CUMULATIVE BILIARY EXCRETION OF RHEIN WAS 1.34(DL)-0.44% OF DOSE 48H
AFTER DOSING AT 500MG/KG OF ONPI-TO IN MALE RATS. |