| Disease | DRUGS, WHICH ELEVAGTE BRAIN SEROTONIN AND EVOKE NEGATIVE FEEDBACK CONTROL OF SEROTONERGIC NEURONS.
SEROTONERGIC NEURONS TO THE 5-HT1A AGONIST 8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN (8-OH-DPAT) (10 UG/KG, I.V.). OVERALL, THESE FINDINGS INDICATE THAT THE MODE OF ACTION OF ST. JOHN'S WORT IS DIFFERENT FROM THAT CONVENTIONAL ANTIDPRESSANT
AUTORECEPTORS. THE FAILURE OF ST. JOHN'S WORT TO DEPRESS NEURONAL ACTIVITY CANNOT BE ATTRIBUTED TO AN IMPAIREMENT OF THE 5-HT1A AUTORECEPTOR MECHANISM, SINCE PRETREATMENT WITH JARSIN 300 (300 MG/KG, P.O.) DID NOT ALTER THE RESPONSIVENESS OF
ACTION OF FLUOXETINE AND SERTRALINE (2 MG/KG, P.O.) TWO SELECTIVE SEROTONIN REUPTAKE INHIBITORS (SSRIS), WHICH MARKEDLY DEPRESSED NEURONAL ACTIVITY BY INCREASING THE SYNMAPTIC AVAILABILITY OF SEROTONIN AT INHIBITORY SOMATODENDRITIS 5-HT1A
SYSTEMIC ADMINISTRATION OF TRWO CLINICAL PREPARATION OF ST. JOHN'S WORT, JARSIN 300 (15-600 MG/KG, P.O.) AND HYPERFORAT (0.5-4.0 ML, I.V.). BOTH PREPARATIONS WERE FOUND TO HAVE NO EFFECT ON NEURONAL ACTIVITY. THIS CONTRASTS SHARPLY WITH THE
TO DETERMINE WHETHER ST. JOHN'S WORT AFFECTS THE CENTRAL SEROTONERGIC SYSTEM, THE DISCHARGE RATE OF SEROTONIN-CONTAINING NEURONS IN THE DORSAL RAPHE NUCLEUS OF AWAKE CATS FOLLOWING SYSTEMIC ADMINISTRATION OF NECLEUS OF AWAKE CATS FOLLOWING |