Experiment 802850
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Organism | Empty organism |
| Citation | LOVELL,DP: VAN IERSEL,M: WALTERS,DG: PRICE,RJ: LAKE,BG:. (1999). GENETIC VARIATION IN THE METABOLISM OF COUMARIN IN MOUSE LIVER.. 9(2) |
| Amount utilized | |
| Compound isolated | |
| Disease | COUMARIN 7-HYDROXYLASE WITH DBA/2 AND 129 HAVING HIGH 7-HYDROXYCOUMARIN FORMATION. CBA/CA HAVING INTERMEDIATE LEVELS AND THE OTHER STRAINS LOW LEVELS. THE DIFFERENCES BETWEEN THE STRAINS WAS MUCH LESS PRONOUNCED IN THE MALE MICE. IN ALL STRAINS, THE COUMARIN 3,4-EPOXIDATION PATHWAY WAS THE MAJOR ROUTE OF METABOLISM WITH O-HYDROXYPHENLACETALDEHYDE (O-HPA) AS THE MAJOR METABOLITE. HOWEVER, IN FEAMLES, THERE WAS A MAJOR STRAIN DIFFERENCE IN THE DEGREEE OF METABOLISM TO |
| Dose amount | 50.0 MICROMOLS |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | MOUSE |
| Dose expression | CONC USED |