Experiment 808635
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INTRAGASTRIC |
| Organism | Hypericum perforatum (CLUSIACEAE) |
| Citation | FORNAL,CA: METZLER,CW: MIRESCU,C: STEIN,SK: JACOBS,BL:. (2001). EFFECTS OF STANDARDIZED EXTRACTS OF ST.JOHN'S WORT ON THE SINGLE-UNIT ACTIVITY OF SEROTONERGIC DORSAL RAPHE NEURONS IN AWAKE CATS: COMPARISONS WITH FLUOXETINE AND SERTRALINE.. 25(6) |
| Amount utilized | |
| Compound isolated | |
| Disease | ,I.V.). BOTH PREPARATIONS WERE FOUND TO HAVE NO EFFECT ON NEURONAL ACTIVITY. THE FAILURE OF ST.JOHN'S WORT TO DEPRESS NEURONAL ACTIVITY WAS NOT ATTRIBUTED TO AN IMPAIRMENT OF THE 5-HT(1A) AUTORECEPTOR MECHANISM, SINCE PRETREATMENT WITH JARSIN THE DISCHARGE RATE OF SEROTONIN-CONTAINING NEURONS IN THE DORSAL RAPHE NUCLEUS OF AWAKE CATS WAS MEASURED FOLLOWING SYSTEMIC ADMINISTRATION OF TWO CLINICAL PREPARATIONS OF ST.JOHN'S WORT, JARSIN 300 (15-600 MG/KG,P.O.) AND HYPERFORAT(0.5-4.0 ML 300 (300 MG/KG, P.O.) DID NOT ALTER THE RESPONSIVENESS OF SEROTONERGIC NEURONS TO THE 5-HT(1A) AGONIST 8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN (8-OH-DPAT) (10 MICROG/KG, I.V.). |
| Dose amount | 300.0 MG |
| Number | 1 |
| Qualitative result | INACTIVE |
| Animal | CAT |
| Per unit | KG |
| Dose expression | DOSE |
| Extract | HYDRO-ALCOHOLIC EXT |
| Gender | GIVEN TO BOTH SEXES |