Experiment 808748
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INTRAGASTRIC |
| Organism | Hypericum perforatum (CLUSIACEAE) |
| Citation | MULLER,WE: SINGER,A: WONNEMANN,M: HAFNER,U: ROLLI,M: SCHAFER,C:. (1998). HYPERFORIN REPRESENTS THE NEUROTRANSMITTER REUPTAKE INHIBITING CONSTITUENT OF HYPERICUM EXTRACT.. 31() |
| Amount utilized | |
| Compound isolated | |
| Disease | TREATMENT OF RATS. THE DATA SUGGEST HYPERFORIN AS THE ACTIVE PRINCIPLE OF HYPERICUM EXTRACTS IN BIOCHEMICAL MODELS OF ANTIDEPRESSANT ACTIVITY. HYDROALCOHOLIC HYPERICUM EXTRACT INHIBITS SYNAPTOSOMAL UPTAKE OF SEROTONIN, NOREPINEPHRINE AND DOPAMINE WITH ABOUT SIMILAR AFFINITIES AND LEADS TO A SIGNIFICANT DOWN REGULATION OF CORTICAL BETA-ADRENOCEPTORS AND 5-HT2 RECEPTORS AFTER SUBCHRONIC |
| Dose amount | 240.0 MG |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | KG |
| Dose expression | DOSE |
| Extract | HYDRO-ALCOHOLIC EXT |
| Gender | GIVEN TO BOTH SEXES |