Experiment 808749
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Organism | Hypericum perforatum (CLUSIACEAE) |
| Citation | MULLER,WE: SINGER,A: WONNEMANN,M: HAFNER,U: ROLLI,M: SCHAFER,C:. (1998). HYPERFORIN REPRESENTS THE NEUROTRANSMITTER REUPTAKE INHIBITING CONSTITUENT OF HYPERICUM EXTRACT.. 31() |
| Amount utilized | |
| Compound isolated | |
| Disease | TREATMENT OF RATS. DATA SUGGESTS HYPERFORIN AS THE ACTIVE PRINCIPLE OF HYPERICUM EXTRACTS IN BIOCHEMICAL MODELS OF ANTIDEPRESSANT ACTIVITY. HYDROALCOHOLIC HYPERICUM EXTRACT INHIBITS SYNAPTOSOMAL UPTAKE OF SEROTONIN, NOREPINEPHRINE AND DOPAMINE WITH ABOUT SIMILAR AFFINITIES AND LEADS TO A SIGNIFICANT DOWN REGULATION OF CORTICAL BETA-ADRENOCEPTORS AND 5-HT2 RECEPTORS AFTER SUBCHRONIC |
| Dose amount | 240.0 MG |
| Number | 3 |
| Qualitative result | ACTIVE |
| Per unit | KG |
| Dose expression | DOSE |
| Extract | HYDRO-ALCOHOLIC EXT |