Experiment 808751
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Organism | Empty organism |
| Citation | FISUNOV,A: LOZOVAYA,N: TSINTSADZE,T: CHATTERJEE,S: NOLDNER,M: KRISHTAL,O:. (2000). HYPERFORIN MODULATES GATING OF P-TYPE CA++ CURRENT IN CEREBELLAR PURKINJE NEURONS.. 440(3) |
| Amount utilized | |
| Compound isolated | |
| Disease | I/V CURVE MAXIMUM AND SLOW-DOWN OF THE ACTIVATION KINETICS. HYPERFORIN (0.8 MICROM) SHIFTED THE MAXIMUM CURRENT VOLTAGE RELATIONSHIP BY -8+-2MV. CALMIDAZOLIUM (0.5 MICROM), AN ANTAGONIST OF THE INTRACELLULAR CA++ BINDING PROTEIN CALMODULIN SIGNIFICANTLY INHIBITED THE HYPERFORIN-INDUCED SHIFT OF THE WHOLE CELL,PATCH-CLAMP RECORDINGS FROM ACUTELY ISOLATED CEREBELLAR PURKINJE NEURONS DEMONSTRATE A TWO-STAGE MODULATION OF P-TYPE HIGH VOLTAGE ACTIVATED (HVA) CA++ CURRENT BY A CONSTITUENT OF ST. JOHN'S WORT, HYPERFORIN (0.04-0.8 MICROM). |
| Dose amount | 0.8 MICROMOLS |
| Number | 1 |
| Qualitative result | ACTIVE |
| Dose expression | CONC USED |