Experiment 809890

Worktypes

PHARMACOLOGY OF COMPOUND - IN VIVOANTICANCER AND/OR CYTOTOXICITY MARKER CODESYNTHESIS OF ANALOGSSTRUCTURE-ACTIVITY RELATIONSHIP STUDIES MARKER CODE

Compounds isolated

MAYTANSINE

Details

PropertyValue
Pharmacology
ANTITUMOR ACTIVITY
Administration routeIP
OrganismMaytenus serrata (CELASTRACEAE)
CitationKUPCHAN,SM: SNEDEN,AT: BRANFMAN,AF: HOWIE,GA: REBHUN,LI: MC IVOR,WE: WANG,RW: SCHNAITMAN,TC:. (1978). TUMOR INHIBITORS. 124. STRUCTURAL REQUIREMENTS FOR ANTILEUKEMIC ACTIVITY AMONG THE NATURALLY OCCURRING AND SEMISYNTHETIC MAYTANSINOIDS.. 21()
Amount utilized
Compound isolated
Dose amount25.0 MCG
Number1
Percent yield120%
Qualitative resultSTRONG ACTIVITY
AnimalMOUSE
Per unitKG
Dose expressionDOSE
Expression resultILS