Experiment 813430
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Maytenus buchananii (CELASTRACEAE) |
| Citation | CABANILLAS,F: RODRIGUEZ,V: HALL,SW: BURGESS,MA: BODEY,GP: FREIREICH,EJ:. (1978). PHASE 1 STUDY OF MAYTANSINE USING A 3-DAY SCHEDULE.. 62() |
| Amount utilized | |
| Compound isolated | |
| Disease | THIS WAS A PHASE I STUDY ALL PATIENTS WERE OVER AGE 15 AND HAD METASTATIC MALIGNANT DISEASE-108 COURSES OF DRUG WERE GIVEN GASTROINTESTINAL TOXICITY CONSISTING OF VOMITING + DIARRHEA THAT BECAME MORE SEVERE AS DOSE INCREASED SEVERE DEHYDRATION IN FEW HOURS |
| Dose amount | 0.40 MG |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |