Experiment 813955
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Maytenus buchananii (CELASTRACEAE) |
| Citation | O'CONNELL,MJ: SHANI,A: RUBIN,J: MOERTEL,CG:. (1978). PHASE II. TRIAL OF MAYTANSINE IN PATIENTS WITH ADVANCED COLORECTAL CARCINOMA.. 62() |
| Amount utilized | |
| Compound isolated | |
| Disease | PHASE II TRIAL OF 31 PATIENTS(43-84 YRS),ALL HAVING COLORECTAL ADENOCARCINOMA NAUSEA-VOMITING(33%):DIARRHEA(45%):ALOPECIA(13%):PARESTHESIAS(12%):MYALGIAS(6%):PARALYTIC ILEUS(3%) DOSING WAS FOR 3 CONSECUTIVE DAYS AND REPEATING AT 3 WEEK INTERVALS FOR FIRST 2 CYCLES,THEN Q 4 WKS |
| Dose amount | 0.60 MG |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |