Experiment 817366
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Organism | Empty organism |
| Citation | ZUTSHI,SK: BHAGWAT,AW:. (1977). ESTRAGOL-A PERSISTENT DEPOLARIZING AGENT OF THE SKELETAL MUSCLE MEMBRANE.. 46() |
| Amount utilized | |
| Compound isolated | |
| Disease | ESTRAGOLE CAUSED CONTRACTIONS OF ISOLATED FROG MUSCLES,FOLLOWED BY RELAXATION. THIS ESTRAGOLE-INDUCED EFFECT WAS REDUCED IN K-DEPOLARIZED MUSCLES OR IN THE PRESENCE OF QUINIDINE OR MN. ESTRAGOLE DIMINISHED THE SIZE OF K-INDUCED CONTRACTURE AND SEEMS TO ACT BY PRODUCING A PERSISTENT DEPOLARIZATION OF THE MUSCLE MEMBRANE,EVEN THOUGH ITS CHEMICAL STRUCTURE IS DIFFERENT FROM THAT OF KNOWN MEMBRANE DEPOLARIZING AGENTS. ESTRAGOLE CAUSED CONTRACTIONS OF ISOLATED FROG MUSCLES,FOLLOWED BY RELAXATION. THIS ESTRAGOLE-INDUCED EFFECT WAS REDUCED IN K-DEPOLARIZED MUSCLES OR IN THE PRESENCE OF QUINIDINE OR MN. ESTRAGOLE DIMINISHED THE SIZE OF K-INDUCED CONTRACTURE AND SEEMS TO ACT BY PRODUCING A PERSISTENT DEPOLARIZATION OF THE MUSCLE MEMBRANE,EVEN THOUGH ITS CHEMICAL STRUCTURE IS DIFFERENT FROM THAT OF KNOWN MEMBRANE DEPOLARIZING AGENTS. |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | FROG |
| Dose expression | CONC USED |