Experiment 821376
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV INFUSION |
| Organism | Empty organism |
| Citation | MALAMUD,SC: OHNUMA,T: COFFEY,V: PACIUCCI,PA: WASSERMAN,LR: HOLLAND,JF:. (1984). PHASE I STUDY OF HOMOHARRINGTONINE (HHT) IN 10 DAY SCHEDULE: 6 HR INFUSION DAILY VS CONTINUOUS INFUSION.. () |
| Amount utilized | |
| Compound isolated | |
| Disease | IN THIS PHASE I STUDY ON 29 PATIENTS WITH LEUKEMIA AND LYMPHOMA, A 6 HR DAILY INFUSION SCHEDULE WAS COMPARED WITH CONTINUOUS INFUSION. THE DOSE WAS ESCALATED FROM 0.5 TO 6.0 MG/M2/D. THERE WERE NO REMISSIONS. CARDIOVASCULAR TOXICITY WAS LOWER IN THE CONTINUOUS INFUSION GROUP, AND THEY COULD TOLERATE HIGHER DOSAGES OF THE DRUG. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | EQUIVOCAL |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |