Experiment 821377
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV INFUSION |
| Organism | Empty organism |
| Citation | MALAMUD,SC: OHNUMA,T: COFFEY,V: PACIUCCI,PA: WASSERMAN,LR: HOLLAND,JF:. (1984). PHASE I STUDY OF HOMOHARRINGTONINE (HHT) IN 10 DAY SCHEDULE: 6 HR INFUSION DAILY VS CONTINUOUS INFUSION.. () |
| Amount utilized | |
| Compound isolated | |
| Disease | IN THIS PHASE I STUDY ON PATIENTS WITH LEUKEMIA AND LYMPHOMA, A 6 HR DAILY INFUSION SCHEDULE WAS COMPARED WITH CONTINUOUS INFUSION. THE DOSE WAS EXCALATED FROM 0.5 TO 6.0 MG/M2/D. PATIENTS IN THE SIX HOUR INFUSION GROUP HAD A HIGHER INCIDENCE OF CARDIOVASCULAR COMPLICATIONS. THERE WERE SOME CASES OF LEUKOPENIA AND THROMBOCYTOPENIA IN BOTH GROUPS. OTHER TOXICITIES INCLUDE MUCOSITIS, DIARRHEA, SOME LIVER TOXICITY, BEHAVIOOR EFFECTS AND HYPERGLYCEMIA. |
| Dose amount | VAR |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |