Experiment 825379

Worktypes

EFFECTS DUE TO A COMBINATION OF DRUGSANTICANCER AND/OR CYTOTOXICITY MARKER CODEPHARMACOLOGY OF COMPOUND - IN HUMANS

Compounds isolated

VINDESINE*

Alerts

A MIXTURE OF PURE COMPOUNDS WAS USED TO OBTAIN THE REPORTED EFFECT.

Details

PropertyValue
Pharmacology
ANTITUMOR ACTIVITY
Administration routeIV
OrganismEmpty organism
CitationDAUGAARD,G: HANSEN,HH: RORTH,M:. (1984). PHASE II STUDY OF VINDESINE, CISPLATIN, AND HEXAMETHYLMELAMINE (VCH) IN SMALL CELL CARCINOMA OF THE LUNG.. 68(9)
Amount utilized
Compound isolated
DiseaseIN THIS PHASE II STUDY 42 PATIENTS WITH SMALL CELL CARCINOMA WERE DOSED WITH VINDESINE,DAYS 1 AND 15,HEXAMETHYLMELAMINE (200 MG/SG.M P.O. DAYS 8-22,AND CISPLATIN (75 MG/SG.M IV ON DAY 1) THERE WERE 3 COMPLETE AND 4 PARTIAL REMISSIONS IN PREVIOUSLY UNTREATED PATIENTS (77%) AND 1 COMPLETE AND 7 PARTIAL REMISSIONS IN PREVIOUSLY TREATED PATIENTS (25%).THERE WAS DOSE LIMITING MYELOSUPPRESSION IN 11 PATIENTS.
Dose amount3.0 MG
Number1
Qualitative resultACTIVE
AnimalHUMAN ADULT
Per unitSQ M BODY SURFACE
Dose expressionDOSE