Experiment 825405

Details

PropertyValue
Pharmacology
Administration routeIV
OrganismEmpty organism
CitationMAROUN,JA: FIELDS,AL: PATER,JL: STEWART,DJ: CRIPPS,C: EISENHAUER,E:. (1984). PHASE II STUDY OF ACIVICIN IN COLORECTAL CARCINOMA: A NATIONAL CANCER INSTITUTE OF CANADA STUDY.. 68(9)
Amount utilized
Compound isolated
DiseaseIN THIS PHASE II TRIAL,20 PATIENTS WITH ADVANCED COLORECTAL CANCER WERE TREATED IN DOSES ESCALATING TO 26 MG/SQ.M IN 21 DAYS CYCLES.OF THE 17 PATIENTS EVALUABLE,THERE WAS NO OBJECTIVE RESPONSE.9 PATIENTS HAD STABLE DISEASE. HEMATOLOGICAL TOXICITY WAS MINIMAL.CNS TOXICITY WAS OBSERVED IN 11 PATIENTS CONSISTING OF CONFUSION,DEPRESSION,SLEEPING DIFFICULTY AND SENSE OF UNREALITY AND DIFFICULTY OF CONCENTRATION.
Dose amount15.0 MG
Number1
Qualitative resultEQUIVOCAL
AnimalHUMAN ADULT
Per unitSQ M BODY SURFACE
Dose expressionDOSE