Experiment 831428

Details

PropertyValue
Pharmacology
Administration routeIV INFUSION
OrganismEmpty organism
CitationMACBETH,FR:. (1982). VM26: PHASE I AND II STUDIES.. 7()
Amount utilized
Compound isolated
DiseaseTHIS PAPER REVIEWS THE PHASE I AND II STUDIES OF TENIPOSIDE IN CANCER TREATMENT. TENIPOSIDE IS EFFECTIVE IN TREATING HODGKIN'S DISEASE, NON-HODGKIN'S LYMPHOMA, NEUROBLASTOMA, PRIMARY BRAIN TUMORS AND SMALL CELL CARCINOMA OF THE LUNG. IT SHOWED SOME ACTIVITY IN INTESTINAL CANCERS, BREAST CANCER AND AL LEUKEMIA IN CHILDREN. THE DOSE LIMITING TOXICITY IS BONE MARROW SUPPRESSION. LESS COMMON TOXICITY INCLUDE HYPOTENSION, SEIZURE, ANAPHYLAXIS, RAISED SERUM SGOT AND HYPERTHERMIA.
Dose amountVAR
Number1
Qualitative resultACTIVE
AnimalHUMAN ADULT
Dose expressionDOSE