Experiment 831700

Worktypes

PHARMACOLOGY OF COMPOUND - IN VIVOEFFECTS DUE TO A COMBINATION OF DRUGSANTICANCER AND/OR CYTOTOXICITY MARKER CODE

Compounds isolated

BESTATIN

Alerts

A MIXTURE OF PURE COMPOUNDS WAS USED TO OBTAIN THE REPORTED EFFECT.

Details

PropertyValue
Pharmacology
ANTITUMOR ACTIVITY
Administration routeGASTRIC INTUBATION
OrganismEmpty organism
CitationABE,F: SHIBUYA,K: ASHIZAWA,J: TAKAHASHI,K: HORINISHI,H: MATSUDA,A: ISHIZUKA,M: TAKEUCHI,T: UMEZAWA,H:. (1985). ENHANCEMENT OF ANTITUMOR EFFECT OF CYTOTOXIC AGENTS BY BESTATIN.. 38(3)
Amount utilized
Compound isolated
DiseaseDOSING ON DAYS 1-6 OR 9-14. BESTATIN WAS GIVEN WITH MITOMYCIN C (1.25 MG/K),5-FU (30 MG/KG) OR CIS-DICHLORODIAMMINEPLATINUM (1 MG/KG) (THESE DRUGS WERE GIVEN ON DAY 7 AND 8). BESTATIN WAS MOST EFFECTIVE WHEN GIVEN AFTER TREATMENT WITH OTHER DRUGS.
Dose amount5.0 MG
Number1
Qualitative resultACTIVE
AnimalMOUSE
Per unitKG
Dose expressionDOSE