Experiment 838297

Worktypes

PHARMACOLOGY OF COMPOUND - IN VIVOCARCINOGENIC DATA (MARKER CODE)TOXICITY MARKER CODE

Compounds isolated

ARECOLINE

Alerts

HISTOPATHOLOGY DATA ARE PRESENTED AND DISCUSSED.METABOLIC ACTIVATION REQUIRED TO OBTAIN POSITIVE RESULTS.

Details

PropertyValue
Pharmacology
CARCINOGENIC ACTIVITY
Administration routeSC
OrganismEmpty organism
CitationWENKE,G: RIVENSON,A: HOFFMANN,D:. (1984). A STUDY OF BETEL QUID CARCINOGENESIS. 3. 3-(METHYLNITROSAMINO)-PROPIONITRILE, A POWERFUL CARCINOGEN IN F344 RATS.. 5(9)
Amount utilized
Compound isolated
DiseaseUNDER MILD NITROSATION ARECOLINE BECOMES THE CARCINOGEN 3-METHYLNITROSAMINOPROPRIONITRILE (MNPN). MNPN, NOT ARECOLINE, WAS USED IN THESE EXPERIMENTS. ANIMALS DEVELOPED PAPILLOMAS AND CARCINOMAS OF THE ESOPHANGUS, NASAL CAVITIES, TONGUE, PHARYNX AND FORE-STOMACH.
Dose amount1.1 MILLIMOLS
Number1
Qualitative resultACTIVE
AnimalRAT
Dose expressionDOSE