Experiment 838418

Worktypes

PHARMACOLOGY OF COMPOUND - IN VIVOEFFECTS DUE TO A COMBINATION OF DRUGS

Compounds isolated

TOOSENDANIN

Alerts

HISTOPATHOLOGY DATA ARE PRESENTED AND DISCUSSED.A MIXTURE OF PURE COMPOUNDS WAS USED TO OBTAIN THE REPORTED EFFECT.

Details

PropertyValue
Pharmacology
NEUROMUSCULAR TOXICITY
Administration routeSC
OrganismEmpty organism
CitationXIONG,CS:. (1985). THE INTERACTION BETWEEN TOOSENDANIN AND BOTULINUS TOXIN AT THE NEUROMUSCULAR JUNCTION, AN ULTRASTRUCTURAL OBSERVATION.. 20(7)
Amount utilized
Compound isolated
DiseaseANIMALS WERE ALSO DOSED WITH TYPE A BOTULINUM TOXIN. ULTRASTRUCTURAL CHANGES CONSISTED OF A DECREASE IN SYNAPTIC VESICLE NUMBER AND AN INCREASE IN ELONGATED VESICLE NUMBER. MYELOID BODY OR PHAGOSOME-LIKE STRUCTURES COULD BE SEEN MORE FREQUENTLY.
Dose amount9.0 MG
Number2
Qualitative resultACTIVE
AnimalMOUSE
Per unitKG
Dose expressionDOSE