Experiment 838622
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV INFUSION |
| Organism | Empty organism |
| Citation | HARVEY,JH: MC FADDEN,M: ANDREWS,WG: BYRNE,PJ: AHLGREN,JD: WOOLLEY,PV:. (1985). PHASE I STUDY OF ECHINOMYCIN ADMINISTERED ON AN INTERMITTENT BOLUS SCHEDULE.. 69(12) |
| Amount utilized | |
| Compound isolated | |
| Disease | IN THIS PHASE I STUDY, 64 PATIENTS WITH ADVANCED CANCER REFRACTORY TO STANDARD THERAPY WERE TREATED. THE DRUG WAS ADMINISTERED ONCE EVERY 4 WEEKS AT 10 DOSE LEVELS RANGING BETWEEN 20 AND 1800 UQ/SQ.M. NO OBJECTIVE TUMOR RESPONSES WERE SEEN. AT DOSES GREATER THAN 1000 UQ/SQ.M ACUTE GASTROINTESTINAL TOXICITY, TRANSIENT ELEVATION OF SERUM TRANSAMINASES, AND THROMBOCYTOPENIA WERE OBSERVED. THREE PATIENTS EXPERIENCED ANAPHYLACTIC REACTIONS TO DOSES OF 1500 UQ/SQ.M. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | EQUIVOCAL |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |