Experiment 838833
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IP |
| Organism | Empty organism |
| Citation | CLARK,JT: SMITH,ER: DAVIDSON,JM:. (1984). ENHANCEMENT OF SEXUAL MOTIVATION IN MALE RATS BY YOHIMBINE.. 225(4664) |
| Amount utilized | |
| Compound isolated | |
| Disease | THIRTY SEXUALLY VIGOROUS RATS WERE DOSED WITH EITHER YOHIMBINE OR VEHICLE. TWENTY MINUTES LATER THE GENITAL AREA WAS ANESTHETIZED AND THEY WERE SUBJECTED TO MOUNTING TESTS FOR 15 MIN. YOHIMBINE TREATED MICE EXHIBITED TWICE AS MUCH MOUNTING BEHAVIOR AS CONTROLS. IN A SECOND TEST, HETEROSEXUALLY NAIVE RATS WERE SUBJECTED TO MATING TESTS 20 MINUTES AFTER YOHIMBINE INJECTION. THIS TEST IS BASED ON THE OBSERVATION THAT A SIGNIFICANT THOUGH VARIABLE PROPORTION OF INEXPERIENCED MALE RATS. DO NOT MATE UPON FIRST EXPOSURE TO A SEXUALLY RECEPTIVE FEMALE. MOST OF THE ANIMALS IN EACH TREATMENT GROUP MATED ON THE INITIAL MATING TEST. HOWEVER, MORE OR THE ANIMALS TREATED WITH YOHIMBINE MOUNTED AND INTROMITTED AND SIGNIFICANTLY MORE EJACULATED. YOHIMBINE TREATED ANIMALS INITIATED COPULATION SIGNIFICANTLY SOONER, AND DEMONSTRATED A NONSIGNIFICANT TREND TOWARD DECREASED EJACULATORY LATENCY AND INTERCOPULATORY INTERVAL. WHEN TESTS WERE REPEATED SEVEN DAYS LATER, THE TWO GROUPS DID NOT DIFFER IN ANY PARAMETER. IN A THIRD TEST, THOSE RATS THAT DID NOT COPULATE EVEN AFTER SIX EXPOSURES TO RECEPTIVE FEMALES, WHERE TESTED FIRST WITH VEHICLE AND ONE WEEK LATER WITH YOHIMBINE. AFTER THE CONTROL TREATMENT, NONE OF THE RATS MATED. HOWEVER, WHEN THEY WERE TREATED WITH YOHIMBINE, COPULATORY ACTIVITY WAS INDUCED IN MOST OF THESE PREVIOUSLY INACTIVE ANIMALS. THIS ACTIVITY WAS WITHIN NORMAL RANGE OF OTHER MALE RATS. |
| Dose amount | 2.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | KG |
| Dose expression | DOSE |
| Gender | MALE |