Experiment 840541
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IP |
| Organism | Empty organism |
| Citation | HATCH,RC: JAIN,AV: WEISS,R: CLARK,JD:. (1982). TOXICOLOGIC STUDY OF CARBOXYATRACTYLOSIDE (ACTIVE PRINCIPLE IN COCKLEBUR-XANTHIUM STRUMARIUM) IN RATS TREATED WITH ENZYME INDUCERS AND INHIBITORS AND GLUTATHIONE PRECURSOR AND DEPLETOR.. 43() |
| Amount utilized | |
| Compound isolated | |
| Disease | DATA GATHERED INDICATED THAT THIS COMPOUND HAS INDEPENDENT LETHAL AND CYTOTOXICITY COMPONENTS. THE CYTOTOXICITY COULD BE PARTLY DUE TO AN ACTIVE METABOLITE FORMED BY DE NOVO SYNTHESIZED CYTOCHROME P450/P448. DETOXIFICATION COULD BE DUE PARTLY TO HEMOPROTEIN-INDEPENDENT ENZYME. THIS COMPOUNDS DETOXIFICATION IS APPARENTLY NOT DEPENDENT ON CYTOCHROME P450 OR GSH. |
| Dose amount | 13.5 MG |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | KG |
| Dose expression | DOSE |