Experiment 841307

Details

PropertyValue
Pharmacology
Administration routeGASTRIC INTUBATION
OrganismEmpty organism
CitationSANGSTER,SA: CALDWELL,J: SMITH,RL:. (1984). METABOLISM OF ANETHOLE. II. INFLUENCE OF DOSE SIZE ON THE ROUTE OF METABOLISM OF TRANS-ANETHOLE IN THE RAT AND MOUSE.. 22(9)
Amount utilized
Compound isolated
DiseaseTHE DOSE RANGE USED WAS FROM 0.05 TO 1500 MG/KG. THE MAJOR ROUTE OF METABOLISM WAS THROUGH O-DEMETHYLATION, 56% IN LOW DOSE GROUPS, AND 32% IN HIGH DOSE GROUPS. SIDE CHAIN OXIDATION WAS REGIOSELECTIVE FAVORING THE EPOXIDATION ROUTE, RESULTING IN THE ELIMINATION OF TWO 1-(4'-METHOXYPHENYL)PROPANE-1,2-DIOL ISOMERS IN THE URINE WHICH ROSE FROM 2 TO 15% OVER THE DOSE RANGE STUDIED.
Dose amountVAR
Number2
Qualitative result.
AnimalRAT
Dose expressionDOSE
GenderFEMALE