Experiment 856369

Compounds isolated

Details

PropertyValue
Pharmacology
Administration routeIV INFUSION
OrganismEmpty organism
CitationLONGNECKER,SM: DONEHOWER,RC: CATES,AE: CHEN,TL: BRUNDRETT,RB: GROCHOW,LB: ETTINGER,DS: COLVIN,M:. (1987). HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC ASSAY FOR TAXOL IN HUMAN PLASMA AND URINE AND PHARMACOKINETICS IN A PHASE I TRIAL.. 71(1)
Amount utilized
Compound isolated
DiseaseA PHASE 1 TRIAL. ALPHA HALF LIFE 16.2 MIN, BETA HALF LIFE 6.4 HOURS, VOLUME OF DISTRIBUTION FOR CENTRAL COMPARTMENT 8.6 L/SQ.M., AT STEADY STATE 67.1 L/SQ.M. MEAN PLASMA CLEARANCE 253 ML/MIN/SQ.M., URINARY CLEARANCE 29.3 ML/MIN/SQ.M. DOSE RANGE 15 TO 265 MG/SQ.M BY 60 TO 360 MIN INFUSION.
Dose amountVAR
Number2
Qualitative resultACTIVE
AnimalHUMAN ADULT
Dose expressionDOSE