Experiment 874486
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | GASTRIC INTUBATION |
| Organism | Ginkgo biloba (GINKGOACEAE) |
| Citation | MOREAU,JP: ECK,CR: MC CABE,J: SKINNER,S:. (1986). ABSORPTION, DISTRIBUTION AND ELIMINATION OF RADIOLABELLED GINKGO BILOBA LEAVES EXTRACT IN THE RAT.. 15(31) |
| Amount utilized | |
| Compound isolated | |
| Disease | FOLLOWING ADMINISTRATION OF THE EXTRACT, EXPIRED 14C-CO2 REPRESENTED 16% OF THE ADMINISTERED DOSE EXCRETED WITHIN THE FIRST 3 HOURS POST-DOSE OUT OF A TOTAL OF 38% AFTER 72 HOURS. AN ADDITIONAL 21% OF THE ADMINISTERED DOSE WAS ELIMINATED IN THE URINE. THE ABSORPTION OF THE RADIOLABELLED EXTRACT WAS AT LEAST 60%. THE PHARMACOKINETICS OF THE EXTRACT, BASED ON BLOOD SPECIFIC ACTIVITY DATA VERSUS TIME COURSE, WERE CHARACTERISTIC OF A TWO-COMPARTMENT MODEL WITH AN APPARENT FIRST ORDER PHASE AND A BIOLOGICAL HALF-LIFE OF CA. 4.5 HOURS. DURING THE FIRST 3 HOURS, RADIOACTIVITY WAS PRIMARILY ASSOCIATED WITH THE PLASMA, BUT THROUGH A GRADUAL UPTAKE AFTER 48 HOURS. THE SPECIFIC ACTIVITY IN ERYTHROCYTES MATCHED THAT OF PLASMA. A SITE OF ABSORPTION IN THE UPPER GASTROINTESTINAL TRACT IS SUSPECTED SINCE SPECIFIC ACTIVITY IN BLOOD PEAKED AFTER 1.5 HOURS. GLANDULAR AND NEURONAL TISSUES AND EYES SHOWED A HIGH AFFINITY FOR THE LABELLED SUBSTANCE. THESE RESULTS PROVIDE THE FIRST TENTATIVE LINK BETWEEN THE THERAPEUTIC EFFECTIVENESS OF GINKGO BILOBA EXTRACT AND THE BIOLOGICAL FATE OF SOME OF ITS CONSTITUENTS. |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Dose expression | DOSE |
| Extract | ETOH(95%)EXT |