Experiment 884203
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Nicotiana glauca (SOLANACEAE) |
| Citation | CASTORENA,JL: GARRIOTT,JC: BARNHARDT,FE: SHAW,RF:. (1987). A FATAL POISONING FROM NICOTIANA GLAUCA.. 25(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | A YOUNG ADULT MALE WAS FOUND DEAD IN A FIELD. A GREEN, LEAFY MATERIAL WAS FOUND IN THE MOUTH AND STOMACH. MODERATE CONGESTION AND EDEMA WAS OBSERVED IN BOTH LUNGS. A VEGETABLE-LIKE MATERIAL WAS FOUND IN THE MORE DISTAL TRACHEOBRONCHIAL TREE. ALL TOXICOLOGICAL SCREENS WERE NEGATIVE EXCEPT FOR WHAT PROVED TO BE ANABASINE IN THE LIVER. A PLANT (NICOTIANA GLAUCA) WAS FOUND IN THE FIELD. ANABASINE WAS SUBSEQUENTLY FOUND IN ALL BODY SAMPLES. DEATH ATTRIBUTED TO CONSUMPTION OF N. GLAUCA LEAVES AND CONSEQUENT ANABASINE POISONING. BLOOD LEVEL OF ANABASINE WAS 1.15 MG/L, CONSIDERABLY LOWER THAN THE CONCENTRATION OF NICOTINE OBSERVED IN FATAL POISONINGS, WHICH RANGES FROM 5-5800 MG/L. |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Extract | LEAVES |