Experiment 891539
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV INFUSION |
| Organism | Empty organism |
| Citation | KUHN,JG: VON HOFF,DD: HERSH,M: MELINK,T: CLARK,GM: WEISS,GR: COLTMAN,CA:. (1989). PHASE I TRIAL OF ECHINOMYCIN (NSC 526417), A BIFUNCTIONAL INTERCALATING AGENT,S ADMINISTERED BY 24-HOUR CONTINUOUS INFUSION.. 25(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | 43 PATIENTS WITH ADVANCED CANCER WERE STUDIED. THE DOSE-LIMITING TOXICITIES OF THE DRUG ADMINISTERED AS A 24 HR CONTINUOUS INFUSION EVERY 28 DAYS WERE NAUSEA AND VOMITING BEGINNING AT THE END OF THE 24 HR INFUSION AND LASTING FROM 3 TO 8 DAYS. OTHER TOXICITIES INCLUDED SPORADIC THROMOBOCYTOPENIA AND BIOCHEMICAL EVIDENCE OF LIVER DYSFUNCTION CHARACTERIZED BY ELEVATION IN SGOT. PERIPHERAL VEIN PHLEBITIS WAS NOTED IN 100% OF PATIENTS, AND WATERY DIARRHEA OF 24-48 HR DURATION WAS NOTED IN 7% OF PATIENTS. |
| Dose amount | 2.13 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | SQ M BODY SURFACE |
| Dose expression | MAXIMUM TOLERATED DOSE |