Experiment 9004
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | GASTRIC INTUBATION |
| Organism | Ceanothus americanus (RHAMNACEAE) |
| Citation | KOPPANYI,T:. (1928). THE EFFECT OF CEANOTHYN UPON THE KIDNEY AND LIVER OF THE DOG.. 17() |
| Amount utilized | |
| Compound isolated | |
| Disease | A COMMERICAL HYDROALCOHOLIC EXTRACT OF THE TITLE PLANT WAS ADMINISTERED BY STOMACH TUBE TO 3 DOGS. THE EFFECT ON THE KIDNEYS WAS DETERMINED BY ROWNTREE'S PHENOLSULFONTHALEIN TEST AND BY NECROPSY AND HISTOLOGICAL EXAMINATION, ACTION ON THE LIVER WAS BY GROSS MICROSCOPIC EXAMINATION. THE DOGS WERE DOSED DAILY FOR 17 DAYS. TOTAL DOSAGE FOR EACH ANIMAL WAS CA.1900 ML.IT WAS ESTIMATED THAT THE DOSE EMPLOYED WAS 30-40 TIMES THE DAILY HUMAN DOSE. NO DETECTABLE IMPAIRMENT OF THE KIDNEYS OR LIVER WAS SHOWN IN THE DOGS BASED ON FUNCTIONAL AND MORPHOLOGICAL STUDIES. |
| Dose amount | 125.0 ML |
| Number | 1 |
| Qualitative result | INACTIVE |
| Animal | DOG |
| Per unit | ANIMAL |
| Dose expression | DOSE |
| Extract | ETOH(20%)EXT |
| Gender | FEMALE |