Experiment 912327
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ROUTE NOT GIVEN |
| Organism | Empty organism |
| Citation | HRUBAN,RH: YARDLEY,JH: DONEHOWER,RC: BOINOTT,JK:. (1989). TAXOL TOXICITY. EPITHELIAL NECROSIS IN THE GASTROINTESTINAL TRACT ASSOCIATED WITH POLYMERIZED MICROTUBULE ACCUMULATION AND MITOTIC ARREST.. 63(10) |
| Amount utilized | |
| Compound isolated | |
| Disease | A 24 YR OLD MALE WITH ACUTE LYMPHOCYTIC LEUKEMIA WAS TREATED WITH A TRIAL OF TAXOL. HIS FIRST COURSE OF TAXOL WAS COMPLICATED BY DIARRHEA, PARESTHESIAS AND ARTHRALGIA. HIS SECOND COURSE WAS COMPLICATED BY ORAL MUCOSITIS, ARRESTED MITOSES WITH DISPERSED CHROMOSOMES IDENTIFIED IN THE ESOPHAGUS, STOMACH, SMALL INTESTINE, COLON AND BONE MARROW. FIRST COURSE OF TAXOL WAS 250 MG/SQ.M., SECOND COURSE WAS 390 MG/SQ.M. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |