Experiment 917103

Details

PropertyValue
Pharmacology
Administration routeINTRAGASTRIC
OrganismCroton penduliflorus (EUPHORBIACEAE)
CitationASUZU,IU: SHETTY,SN: ANIKA,SM:. (1989). THE TOXIC EFFECTS OF A CHRONIC ADMINISTRATION OF THE GUT-STIMULATING PRINCIPLE IN CROTON PENDULIFLORUS HUTCH. SEEDS IN MICE.. 12(1)
Amount utilized
Compound isolated
DiseaseTHE GUT STIMULATING PRINCIPLE FROM CROTON PENDULIFLORUS WAS A MIXTURE OF PALMITIC, STEARIC AND ARACHIDIC ACIDS (EQUAL AMOUNTS). THIS MIXTURE WAS TESTED. THE MIXTURE PRODUCED SEVERE LESIONS IN THE VISCERAL ORGANS AND THE BRAIN AFTER CHRONIC ORAL ADMINISTRATION AT LOW AND HIGH DOSAGE LEVELS. GOBLET CELL HYPERPLASIA WITH MUCIN PRESENT IN THE LUMEN WAS OBSERVED IN THE JEJUNUM, ILEUM AND COLON. HISTOPATHOLOGICAL CHANGES OBSERVED INCLUDED HAEMORRHAGE IN THE LUNGS, MYOCARDIUM, LIVER, KIDNEY, TESTIS, BRAIN, ETC.
Dose amount2-21 MG
Number2
Qualitative resultACTIVE
AnimalMOUSE
Per unitKG
Dose expressionDOSE
GenderGIVEN TO BOTH SEXES