Experiment 917948
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV INFUSION |
| Organism | Empty organism |
| Citation | LEGHA,SS: RING,S: PAPADOPOULOS,N: RABER,M: BENJAMIN,RS:. (1990). A PHASE II TRIAL OF TAXOL IN METASTATIC MELANOMA.. 65(11) |
| Amount utilized | |
| Compound isolated | |
| Disease | THIS WAS A PHASE II CLINICAL TRIAL IN 25 PATIENTS WITH METASTATIC MELANOMA WHO WERE PREVIOUSLY UNTREATED. DOSING WAS STARTED AT 250 MG/SQ M DELIVERED AS A CONTINUOUS IV INFUSION OVER 24 HOURS AT 3 WEEK INTERVALS. ALL PATIENTS WERE PREMEDICATED WITH ORAL DEXAMETHASONE AND IV DIPHENHYDRAMINE HCL AS PROPHYLAXIS AGAINST ALLERGIC REACTIONS. THREE OF 25 PATIENTS HAD A PARTIAL RESPONSE(PR) FOUR PATIENTS HAD OBJECTIVE REGRESSION OF TUMOR THAT FAILED TO QUALIFY FOR A PR BUT THESE RESPONSES WERE AS DURABLE, LASTING 6-17 MONTHS. NO PATIENTS EXPERIENCED ACUTE ALLERGIC REACTIONS. THE MAJOR TOXICITY WAS NEUTROPENIA REQUIRING DOSE REDUCTION TO 200 MG/SQ M IN A MAJORITY OF PATIENTS. IT WAS CONCLUDED THAT TAXOL HAS DEFINITE THOUGH LIMITED ACTIVITY AGAINST METASTATIC MELANOMA. |
| Dose amount | 250.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |