Experiment 920081
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ROUTE NOT GIVEN |
| Organism | Canavalia ensiformis (FABACEAE) |
| Citation | RIBEIRO-DA SILVA,G: COLLARES,CB: PRADO,JF:. (1990). THE HYPOGLYCEMIA PRODUCED BY CANATOXIN IN RATS PROBABLY HAS A CENTRAL MECHANISM AND SEEMS TO BE MODULATED BY ENDOGENOUS APIOIDS.. 28(6) |
| Amount utilized | |
| Compound isolated | |
| Disease | CANATOXIN-INDUCED HYPOGLYCEMIA WAS BLOCKED BY HEXAMETHONIUM OR ATROPINE AND ALSO BY NALOXONE OR NALTREXON. IT WAS ALSO DEMONSTRATED THAT CANATOXIN PRODUCES A TIME AND DOSE DEPENDENT HYPOGLYCEMIA WHEN INJECTED INTO THE BRAIN'S LATERAL VENTRICLE. IT WAS CONCLUDED THAT THE HYPOGLYCEMIA PRODUCED BY CANATOXIN IS A CENTRAL EFFECT AND DEPENDS ON PARASYMPATHETIC STIMULATION AND THAT THERE IS AN INVOLVEMENT OF THE ENDOGENOUS OPIOID SYSTEM. |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Dose expression | DOSE |