Experiment 927465
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Empty organism |
| Citation | STEWART,CF: ARBUCK,SG: FLEMING,RA: EVANS,WE:. (1990). CHANGES IN THE CLEARANCE OF TOTAL AND UNBOUND ETOPOSIDE IN PATIENTS WITH LIVER DYSFUNCTION.. 8(11) |
| Amount utilized | |
| Compound isolated | |
| Disease | 17 PATIENTS WITH PANCREATIC, HEPATOBILIARY OR UPPER GI TUMORS WERE USED IN THIS STUDY. 4 PATIENTS WITH TUMORS OF UNKOWN ORIGIN WERE ALSO USED. TOTAL SYSTEMIC CLEARANCE OF ETOPOSIDE WAS HIGHER IN PATENTS WITH ABNORMALLY HIGH BILIRUBIN LEVELS(1.1 TO 21.5 MG/DL). UNBOUND ETOPOSIDE CLEARANCE WAS SIGNIFICANTLY LOWER IN PATIENTS WITH HIGH BILIRUBIN LEVELS. ETOPOSIDE WAS GIVEN EVERY OTHER DAY FOR UP TO 3 DOSES. CIPLATIN WAS ALSO GIVEN TO PATIENTS IN A DOSE OF 70 MG/SQ.M. ON DAY 1. |
| Dose amount | 100.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |