Experiment 927706
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | CANTWELL,BMJ: MILLWARD,MJ: LIND,MJ: CALVERT,AH:. (1990). 21-DAY CYCLES OF ORAL ETOPOSIDE IN HEAVILY PRETREATED METASTATIC GERM-CELL CANCER.. 336(8721) |
| Amount utilized | |
| Compound isolated | |
| Disease | 6 PATIENTS WITH METASTATIC GERM CELL CANCER WERE USED IN THIS STUDY. PATIENTS WERE GIVEN ETOPOSIDE DAILY FOR 21 DAY CYCLES WITH 7 DAY BREAKS BETWEEN CYCLES. 3 PATIENTS SHOWED NO TUMOR RESPONSE, IN 1 DISEASE DID NOT PROGRESS FOR 6 MONTHS AFTER THERAPY AND 2 HAD RAPID TUMOR PROGRESSION. TOXICITIES INCLUDED MYELOSUPPRESSION IN ALL PATIENTS, AS WELL AS LEUKOPENIA AND THROMBOCYTOPENIA. DURING DOSING, 2 PATIENTS WERE GIVEN CISPLATIN IN INTRAVENOUS DOSES OF 20 MG/SQ.M. WHILE 1 WAS GIVEN A DOSE OF 30 MG/SQ.M. |
| Dose amount | 100.0 MG |
| Number | 1 |
| Qualitative result | EQUIVOCAL |
| Animal | HUMAN ADULT |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |