Experiment 928148
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | NISHIKAWA,M: YOSHIDA,K: OKAMOTO,M: KOHSAKA,M:. (1990). STUDIES ON WF-3681, A NOVEL ALDOSE REDUCTASE INHIBITOR. III. EFFECTS OF WF-3681 AND ITS DERIVATIVES ON SORBITOL ACCUMULATION IN DIABETIC RATS.. 43(9) |
| Amount utilized | |
| Compound isolated | |
| Disease | 7 WEEK OLD RATS, AFTER BEING MADE DIABETIC BY INJECTION OF STREPTOZOTOCIN, WERE GIVEN DOSE SUSPENDED IN 0.5% METHYL CELLULOSE DAILY FOR 5 DAYS. THE SCIATIC NERVE WAS THEN EXCISED AND ASSAYED FOR SORBITOL, WHICH WAS FOUND TO BE INHIBITED BY 23%. |
| Dose amount | 32.0 MICROMOLS |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | KG |
| Dose expression | DOSE |
| Gender | MALE |